Opportunity Information: Apply for PAR 17 321
The Multidisciplinary Studies of HIV/AIDS and Aging (R01) funding opportunity (PAR 17-321) is a National Institutes of Health (NIH) discretionary grant designed to support research that sits squarely at the crossroads of HIV and the science of aging. The central idea is that the growing population of people living with HIV, many of whom are now reaching older ages due to effective antiretroviral therapy, creates both an urgent public health need and a unique scientific window into how aging works. Projects are expected to be multidisciplinary and to generate knowledge that is useful both for improving HIV-related health outcomes and for advancing broader understanding of aging processes.
The FOA lays out two big, interconnected objectives. First, it aims to improve understanding of the biological, clinical, and socio-behavioral aspects of aging by using HIV infection and its treatment as a lens. That means applicants might examine how long-term HIV infection, chronic inflammation, immune system changes, or cumulative treatment exposure interact with typical aging pathways, and how these interactions show up in real-world health outcomes. It also explicitly opens the door to work on clinical and behavioral dimensions, such as how aging with HIV affects cognition, mental health, functional status, medication adherence, social support, stigma, and quality of life, including how these factors differ across groups and settings.
Second, the FOA seeks to improve HIV testing, prevention, and treatment approaches, as well as the management of HIV-related comorbidities, co-infections, and complications, by applying current aging science. In practice, this encourages investigators to use what is known about aging biology, geriatric care, and age-related risk factors to develop or refine interventions for people with HIV across the lifespan, especially older adults. This could include strategies to prevent or better manage conditions that commonly cluster with aging and HIV (for example, cardiovascular disease, metabolic disorders, frailty, neurocognitive complications, osteoporosis, renal disease, and multimorbidity), as well as co-infections and long-term complications that can be shaped by immune aging. The FOA also emphasizes relevance across different populations and cultural settings, signaling interest in research that is attentive to diversity, context, and implementation realities rather than focusing on a single narrow population.
A key expectation is alignment with the NIH Office of AIDS Research (OAR) scientific priorities, specifically those described in NOT-OD-15-137. In other words, applicants should frame aims and significance in a way that maps to NIH-wide HIV/AIDS research priorities, not only to institute-specific interests. This kind of alignment often matters in peer review because it shows that the project fits the broader strategic direction for federal HIV research investments.
The funding mechanism is an R01, meaning it supports discrete, investigator-initiated research projects that typically involve substantial hypothesis-driven or conceptually rigorous work, often with multiple aims and a well-developed approach. The opportunity is categorized under the broad activity areas of education and health, and it is associated with multiple CFDA numbers (including 93.121, 93.213, 93.242, 93.279, 93.361, 93.393 through 93.399, 93.846, 93.853, and 93.866), reflecting the cross-cutting nature of HIV and aging research across NIH components. The source data does not specify an award ceiling or the expected number of awards, so applicants would generally look to the full FOA and NIH institute/center budgets for practical expectations about project scale.
Eligibility is intentionally broad, which fits the multidisciplinary focus and the fact that impactful HIV and aging research can originate in many settings. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations (other than small businesses); small businesses; and other entities. The FOA also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. (foreign) organizations. That breadth signals a real interest in expanding where ideas come from and ensuring research can be conducted in diverse communities and geographic regions, including outside the United States when scientifically justified.
Administratively, the opportunity was created on 2017-06-23 and listed an original closing date of 2020-09-07 in the provided source data. While those dates help place the FOA historically, applicants typically need to confirm the current status of the announcement (for example, whether it has been reissued, expired, or replaced) before preparing an application, since NIH FOAs often have defined cycles and may be updated over time.
Overall, this FOA is best understood as an invitation to propose rigorous R01-level research that treats HIV and aging as intertwined challenges: using HIV as a model to deepen aging science, and using aging science to improve HIV prevention, treatment, and long-term management of comorbidities and complications. It encourages work that spans biology, clinical care, and socio-behavioral dimensions, and it places value on applicability across different populations and cultural contexts, consistent with NIH OAR priorities.Apply for PAR 17 321
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Multidisciplinary Studies of HIV/AIDS and Aging (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.213, 93.242, 93.279, 93.361, 93.393, 93.394, 93.395, 93.396, 93.399, 93.846, 93.853, 93.866.
- This funding opportunity was created on 2017-06-23.
- Applicants must submit their applications by 2020-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs): Multidisciplinary Studies of HIV/AIDS and Aging (R01) (PAR-17-321)
What is the Multidisciplinary Studies of HIV/AIDS and Aging (R01) opportunity (PAR-17-321)?
PAR-17-321 is a National Institutes of Health (NIH) discretionary funding opportunity using the R01 mechanism to support multidisciplinary research at the intersection of HIV/AIDS and the science of aging. It invites projects that generate knowledge useful for improving HIV-related health outcomes and for advancing broader understanding of aging processes.
What is the main purpose of this funding opportunity?
The central idea is that more people are living to older ages with HIV due to effective antiretroviral therapy, creating both an urgent public health need and a unique scientific opportunity to study how aging works. The FOA supports research that treats HIV and aging as intertwined challenges and opportunities.
What are the two major objectives described in the FOA?
The FOA describes two interconnected objectives: (1) improving understanding of the biological, clinical, and socio-behavioral aspects of aging by using HIV infection and its treatment as a lens; and (2) improving HIV testing, prevention, treatment, and management of HIV-related comorbidities, co-infections, and complications by applying current aging science.
What kinds of research topics fit under the first objective (using HIV as a lens on aging)?
Examples include studying how long-term HIV infection, chronic inflammation, immune system changes, or cumulative treatment exposure interact with aging pathways and how those interactions affect real-world health outcomes. The FOA also explicitly includes clinical and behavioral dimensions such as cognition, mental health, functional status, medication adherence, social support, stigma, and quality of life, including how these differ across groups and settings.
What kinds of research topics fit under the second objective (using aging science to improve HIV outcomes)?
This includes applying aging biology, geriatric care approaches, and age-related risk factor knowledge to develop or refine strategies for HIV testing, prevention, and treatment, as well as for managing comorbidities, co-infections, and long-term complications that may be influenced by immune aging.
Does the FOA emphasize any specific comorbidities or complications?
Yes. The FOA highlights conditions that commonly cluster with aging and HIV, including cardiovascular disease, metabolic disorders, frailty, neurocognitive complications, osteoporosis, renal disease, and multimorbidity. It also mentions co-infections and long-term complications shaped by immune aging.
Is the research expected to be multidisciplinary?
Yes. A core expectation is multidisciplinary research, reflecting that HIV and aging research spans biology, clinical care, and socio-behavioral science.
Is socio-behavioral and mental health research within scope?
Yes. The FOA explicitly invites work on clinical and behavioral dimensions such as cognition, mental health, functional status, adherence, social support, stigma, and quality of life.
Does the FOA focus only on older adults with HIV?
The FOA is motivated by the growing population of older people living with HIV and highlights older adults, but it also discusses improving approaches for people with HIV across the lifespan, especially older adults.
How important is alignment with NIH Office of AIDS Research (OAR) priorities?
Alignment is a key expectation. The FOA calls for alignment with NIH OAR scientific priorities described in NOT-OD-15-137, and it notes that mapping aims and significance to NIH-wide HIV/AIDS research priorities can matter in peer review by demonstrating fit with broader strategic direction.
What funding mechanism is used for this opportunity?
This opportunity uses the R01 mechanism, which supports discrete, investigator-initiated research projects that are typically substantial, hypothesis-driven (or otherwise conceptually rigorous), and often organized around multiple aims and a well-developed approach.
Is this opportunity limited to education or health topics?
The opportunity is categorized under broad activity areas of education and health, reflecting its scope across biomedical, clinical, behavioral, and implementation-relevant research tied to HIV and aging.
Are award limits or the expected number of awards provided?
No. The source information provided does not specify an award ceiling or the expected number of awards. Practical expectations about project scale are typically informed by the full FOA and NIH institute/center budgets.
Who is eligible to apply?
Eligibility is broad and includes (among others) state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations (other than small businesses); small businesses; and other entities.
Are community-based and faith-based organizations eligible?
Yes. The FOA explicitly highlights faith-based and community-based organizations as additional eligible applicants.
Are minority-serving institutions and tribally controlled colleges eligible?
Yes. The FOA explicitly highlights Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs) as additional eligible applicants.
Are U.S. territories or possessions eligible to apply?
Yes. The FOA explicitly lists U.S. territories or possessions as additional eligible applicants.
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA explicitly includes non-U.S. (foreign) organizations among eligible applicants, indicating that research can be conducted outside the United States when scientifically justified.
Does the FOA encourage research across diverse populations and cultural settings?
Yes. The FOA emphasizes relevance across different populations and cultural settings and signals interest in research attentive to diversity, context, and implementation realities rather than a single narrow population.
When was this funding opportunity created, and what closing date is listed?
The source information states the opportunity was created on 2017-06-23 and lists an original closing date of 2020-09-07.
Is the FOA definitely still open based on the information provided?
No. The provided information includes historical dates and notes that applicants typically need to confirm the current status (for example, whether it has been reissued, expired, or replaced) before preparing an application.
What is the overall takeaway on what NIH is looking for in PAR-17-321?
NIH is inviting rigorous, R01-level research that treats HIV and aging as intertwined: using HIV to deepen aging science and using aging science to improve HIV testing, prevention, treatment, and long-term management of comorbidities and complications, with attention to multidisciplinary approaches, real-world relevance, diverse populations, and alignment with NIH OAR priorities.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with multiple CFDA numbers, including 93.121, 93.213, 93.242, 93.279, 93.361, 93.393 through 93.399, 93.846, 93.853, and 93.866, reflecting cross-cutting involvement across NIH components.
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