Opportunity Information: Apply for PA 19 127
The Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required), NIH opportunity number PA 19 127, is a discretionary grant mechanism meant to help early-stage or transitioning researchers build the skills, track record, and leadership experience needed to become independent investigators. The core aim is to provide substantial protected time and structured mentorship for an intensive career development period lasting three to five years. The program supports career development across biomedical, behavioral, and clinical sciences, with the expectation that the award period will position the recipient to compete successfully for independent research funding afterward.
A defining feature of this specific FOA is that it is intended for applicants who will serve as the lead investigator of an independent clinical trial as part of their career development plan. That includes leading a full independent clinical trial, conducting a clinical trial feasibility study, or running a separate ancillary clinical trial tied to a larger parent trial but led independently. In other words, the award is aligned with candidates who are not only training but also taking on primary responsibility for designing and executing a trial-level study. If an applicant is not planning to lead an independent clinical trial, or if they are seeking clinical trial experience primarily as a participant in a trial led by another investigator, they are directed to apply to a companion K01 FOA (listed as XXXX in the provided text) that is structured for non-lead or non-independent trial scenarios.
Across NIH Institutes and Centers, the K01 mechanism is generally used to cultivate research independence, but NIH notes that some participating Institutes and Centers also use K01 awards to support researchers who are retraining into a new scientific field or reentering research after a career interruption due to illness or significant family responsibilities. Separately, NIH indicates that some Institutes and Centers maintain other K01 announcements specifically focused on increasing workforce diversity, which are distinct from this parent announcement.
Eligibility for applicant organizations is broad and spans many parts of the public and private research and service ecosystem. Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; certain tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding higher education institutions in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and other types of organizations. The FOA also explicitly calls out additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American Tribal Governments other than federally recognized entities, and U.S. territories or possessions.
At the same time, the announcement draws clear limits around foreign applicants. Non-domestic (non-U.S.) entities and non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply as the applicant organization. However, foreign components are allowed when they meet the NIH Grants Policy Statement definition, meaning a U.S.-based applicant can include certain foreign elements in the proposed work when well-justified and compliant with NIH policy.
Administrative details in the source data identify the sponsoring agency as the National Institutes of Health, with the funding instrument type listed as a grant and the activity category spanning education, health, and related social service areas. The opportunity is associated with multiple CFDA numbers (including 93.172, 93.173, 93.213, 93.233, 93.273, 93.279, 93.286, 93.837, 93.838, 93.839, 93.840, 93.846, 93.865, and 93.866), reflecting participation across different NIH Institutes and Centers. The record shows an original closing date of 2020-05-07 and a creation date of 2018-12-20; award ceiling and expected awards fields are not specified in the provided listing. Overall, this FOA is best understood as a mentored, time-protected pathway for investigators who want to achieve independence while directly leading an independent clinical trial or closely related trial work as a central part of their research and training plan.Apply for PA 19 127
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172, 93.173, 93.213, 93.233, 93.273, 93.279, 93.286, 93.837, 93.838, 93.839, 93.840, 93.846, 93.865, 93.866.
- This funding opportunity was created on 2018-12-20.
- Applicants must submit their applications by 2020-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 19 127) also looked into and applied for these:
| Funding Opportunity |
|---|
| Mentored Quantitative Research Development Award (Parent K25 - Independent Clinical Trial Not Allowed) Apply for PA 19 124 Funding Number: PA 19 124 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Mentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Not Allowed) Apply for PA 19 126 Funding Number: PA 19 126 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Required) Apply for PA 19 129 Funding Number: PA 19 129 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required) Apply for PAR 19 135 Funding Number: PAR 19 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Accelerating the Pace of Child Health Research Using Existing Data from the Adolescent Brain Cognitive Development (ABCD) Study (R21-Clinical Trial Not Allowed) Apply for PAR 19 163 Funding Number: PAR 19 163 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
| HIV/AIDS Clinical Trials Networks Laboratory Centers (UM1 Clinical Trial Required) Apply for RFA AI 19 001 Funding Number: RFA AI 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV Prevention Clinical Trials Network Leadership and Operations Center (UM1 Clinical Trial Required) Apply for RFA AI 19 005 Funding Number: RFA AI 19 005 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HIV/AIDS Clinical Trials Networks Statistical and Data Management Centers (SDMC) (UM1 Clinical Trial Required) Apply for RFA AI 19 002 Funding Number: RFA AI 19 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (R01 Clinical Trial Optional) Apply for RFA AI 19 022 Funding Number: RFA AI 19 022 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $350,000 |
| U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (HIV/AIDS) (U01 Clinical Trial Optional) Apply for RFA AI 19 023 Funding Number: RFA AI 19 023 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $250,000 |
| BRAIN Initiative: Tools to Facilitate High-Throughput Microconnectivity Analysis (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 135 Funding Number: RFA MH 20 135 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Secondary Analysis and Archiving of BRAIN Initiative Data (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 120 Funding Number: RFA MH 20 120 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| Brain Initiative: Research to Develop and Validate Advanced Human Cell-Based Assays To Model Brain Structure and Function (R01 Clinical Trial Not Allowed) Apply for RFA MH 20 140 Funding Number: RFA MH 20 140 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| "Clinical Trials" on a Chip: Tissue Chips to Inform Clinical Trial Design and Implementation in Precision Medicine (UG3/UH3 - Clinical Trial Not Allowed) Apply for RFA TR 19 014 Funding Number: RFA TR 19 014 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $500,000 |
| BRAIN Initiative: Proof of Concept Development of Early Stage Next Generation Human Brain Imaging (R01 Clinical Trial Not Allowed) Apply for RFA EB 19 001 Funding Number: RFA EB 19 001 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $300,000 |
| BRAIN Initiative: Development of Next Generation Human Brain Imaging Tools and Technologies (U01 Clinical Trial not allowed) Apply for RFA EB 19 002 Funding Number: RFA EB 19 002 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Science of Behavior Change (SOBC) Resource and Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA AG 20 024 Funding Number: RFA AG 20 024 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative: Non-Invasive Neuromodulation - New Tools and Techniques for Spatiotemporal Precision (R01 Clinical Trial Optional) Apply for RFA MH 20 310 Funding Number: RFA MH 20 310 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Clinical Sites for the ECHO IDeA States Pediatric Clinical Trials Network - 2 (UG1 Clinical Trial Required) Apply for RFA OD 19 026 Funding Number: RFA OD 19 026 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $275,000 |
| Small Research Grants for Analyses of Gabriella Miller Kids First Pediatric Research Data (R03 Clinical Trial Not Allowed) Apply for PAR 19 375 Funding Number: PAR 19 375 Agency: National Institutes of Health Category: Education, Health, Income Security and Social Services Funding Amount: $200,000 |
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