Opportunity Information: Apply for PAR 19 376
The National Institutes of Health (NIH) funding opportunity titled "Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional)" (PAR-19-376) supports exploratory and early-stage projects that use mobile health (mHealth) approaches to address important health challenges in low- and middle-income countries (LMICs). The focus is on creating and testing innovative mHealth interventions or tools that fit LMIC contexts and that make use of new or emerging technologies, digital platforms, systems approaches, or advanced analytics. In practical terms, NIH is looking for research that moves beyond simple phone-based messaging and instead pushes toward genuinely innovative, context-appropriate solutions that can be shown to work, be feasible to implement, and meaningfully improve clinical or public health outcomes.
A key goal of the program is to catalyze multidisciplinary innovation in global health by building a stronger evidence base for mHealth. Projects are expected to study one or more stages of the lifecycle of an mHealth solution, such as development and design, validation of measures or performance, feasibility and usability in real-world environments, and early evidence of effectiveness. The FOA is designed to help generate credible data on whether a mobile or digital approach actually improves health outcomes, strengthens service delivery, or supports public health practice in LMIC settings, rather than only demonstrating technical functionality.
The funding mechanism is an R21/R33 phased innovation structure. This typically allows teams to begin with an exploratory, developmental phase (R21) to build and refine the approach and produce strong preliminary data, and then transition to a second phase (R33) to expand testing and generate more robust evidence, assuming predefined milestones are met. The FOA is labeled "Clinical Trial Optional," meaning applicants may propose a clinical trial if it fits the aims, but a clinical trial is not required. This gives flexibility for projects that are more tool-development or implementation focused, as well as those that are ready to test outcomes in a clinical or community setting.
Partnership is a central requirement. Applicants must propose a collaboration that includes at least one U.S.-based institution and at least one LMIC institution. This is meant to ensure that the work is grounded in local priorities, realities, and capacity, and that the research strengthens mHealth research capability in LMICs rather than treating LMIC sites only as field locations. Capacity strengthening is an explicit program goal, so competitive applications generally align technical innovation with training, shared leadership, equitable collaboration practices, and sustained local benefit.
Eligibility is broad and includes many types of organizations that can contribute to global mHealth research. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities); for-profit organizations (other than small businesses); small businesses; public housing authorities/Indian housing authorities; and Native American tribal governments and organizations, including federally recognized tribal governments and other tribal organizations. The FOA also highlights a range of additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, non-U.S. entities/foreign organizations, regional organizations, and U.S. territories or possessions. This broad eligibility reflects NIH's intent to encourage diverse partnerships and practical, on-the-ground innovation capacity.
Administratively, the opportunity is a discretionary NIH grant in the education and health-related activity categories, with CFDA numbers listed as 93.173, 93.242, 93.286, 93.313, 93.399, 93.853, and 93.865. The original closing date shown in the source information is December 3, 2020, and the record creation date is September 13, 2019. The award ceiling and expected number of awards are not specified in the provided source data, which generally means applicants need to consult the full FOA and NIH budget guidance for the specific participating institutes and centers to understand typical budget ranges, project periods, and any institute-specific priorities.
Overall, this FOA is aimed at teams that can combine global health expertise with mobile and digital innovation, produce rigorous evidence about feasibility and outcomes, and do so through a genuine U.S.-LMIC partnership that strengthens research capacity in LMIC settings.Apply for PAR 19 376
- The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Mobile Health: Technology and Outcomes in Low and Middle Income Countries (R21/R33 - Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173, 93.242, 93.286, 93.313, 93.399, 93.853, 93.865.
- This funding opportunity was created on 2019-09-13.
- Applicants must submit their applications by 2020-12-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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